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Piccirilli, Joseph A.
One or more keywords matched the following items that are connected to
Piccirilli, Joseph A.
Item Type
Name
Concept
Models, Molecular
Academic Article
Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli.
Academic Article
The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
Academic Article
Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides.
Academic Article
Synthesis of the phosphoramidite derivative of 2'-deoxy-2'-C-beta-methylcytidine.
Academic Article
Synthesis of the phosphoramidite derivatives of 2'-deoxy-2'-C-alpha-methylcytidine and 2'-deoxy-2'-C-alpha-hydroxymethylcytidine: analogues for chemical dissection of RNA's 2'-hydroxyl group.
Academic Article
A packing-density metric for exploring the interior of folded RNA molecules.
Academic Article
Synthesis of 2'-C-difluoromethylribonucleosides and their enzymatic incorporation into oligonucleotides.
Academic Article
A second divalent metal ion in the group II intron reaction center.
Academic Article
2'-mercaptonucleotide interference reveals regions of close packing within folded RNA molecules.
Academic Article
Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
Academic Article
Crystal structure of the catalytic core of an RNA-polymerase ribozyme.
Academic Article
The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins.
Academic Article
Sin resolvase catalytic activity and oligomerization state are tightly coupled.
Academic Article
Linkage between substrate recognition and catalysis during cleavage of sarcin/ricin loop RNA by restrictocin.
Academic Article
Functional identification of ligands for a catalytic metal ion in group I introns.
Academic Article
The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.
Academic Article
The mechanism of peptidyl transfer catalysis by the ribosome.
Academic Article
Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment.
Academic Article
Tightening of active site interactions en route to the transition state revealed by single-atom substitution in the guanosine-binding site of the Tetrahymena group I ribozyme.
Academic Article
Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry.
Academic Article
Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center.
Academic Article
Recognition of guanosine by dissimilar tRNA methyltransferases.
Academic Article
Modulation of individual steps in group I intron catalysis by a peripheral metal ion.
Academic Article
Structural inference of native and partially folded RNA by high-throughput contact mapping.
Academic Article
Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate.
Academic Article
A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.
Academic Article
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.
Academic Article
Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.
Academic Article
Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage.
Academic Article
Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by aß T cells.
Academic Article
Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation.
Academic Article
Evidence for a group II intron-like catalytic triplex in the spliceosome.
Academic Article
Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations.
Academic Article
A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair.
Academic Article
Enzyme transition states from theory and experiment.
Academic Article
Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism.
Academic Article
Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects.
Academic Article
Reverse transcriptases lend a hand in splicing catalysis.
Academic Article
Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Academic Article
RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.
Academic Article
Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.
Academic Article
Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation.
Academic Article
Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography.
Academic Article
Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.
Academic Article
Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation.
Academic Article
Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures.
Academic Article
The Positively Charged Active Site of the Bacterial Toxin RelE Causes a Large Shift in the General Base pKa.
Academic Article
The SARS-CoV-2 Programmed -1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography.
Search Criteria
Models Molecular